Buy Acetyl Hexapeptide-3 peptide
What Is Acetyl Hexapeptide-3?
Acetyl Hexapeptide-3 — often referred to in the skincare and cosmetic peptide industry as Argireline — is a synthetic six-amino-acid peptide designed to support visible wrinkle reduction, smoother skin texture, and anti-aging benefits in topical formulations. It’s one of the most widely studied and used cosmetic peptides due to its unique ability to inhibit muscle-related wrinkle formation and is considered a non-invasive alternative to injectable neurotoxins.
This premium peptide is ideal for cosmetic labs, serum formulators, and advanced skincare developers seeking a high-quality active ingredient with consistent performance.
How Acetyl Hexapeptide-3 Works
Acetyl Hexapeptide-3 is engineered to mimic a portion of the SNAP-25 protein, a key player in neurotransmitter release at the neuromuscular junction. By competing with natural proteins in the SNARE complex, it interferes with signals that trigger muscle contraction — especially in areas with frequent expression movement (like crow’s feet and forehead lines).
This doesn’t paralyze muscles like Botox injections; rather, it reduces the intensity of muscle contractions over time, contributing to fewer dynamic wrinkles and a smoother skin surface.

Key Benefits
✔️ Reduces Appearance of Expression Lines
When included in serums, creams, or lotions, this peptide can help diminish expression-related facial lines, particularly around the forehead and eye areas.
✔️ Enhances Skin Texture
Regular use has been associated with improved skin smoothness and reduced wrinkle depth due to its role in softening muscle tension at the skin’s surface.
✔️ Non-Invasive & Gentle
Unlike injectable cosmetic treatments, Acetyl Hexapeptide-3 works topically and is typically well-tolerated when formulated correctly; it is considered safe for sensitive skin types.
✔️ Compatible with Modern Skincare Formulations
Its water-soluble nature makes it highly compatible with a variety of anti-aging skincare products, from eye serums to face lotions and daily moisturizer blends.
Why Choose Peptide Metabolic’s Acetyl Hexapeptide-3?
At Peptide Metabolic, we prioritize purity, stability, and scientific integrity:
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Cosmetic-Grade Peptide with reliable quality for R&D and formulation.
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Accurate Batch Testing: HPLC and purity verification on every lot.
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Consistent Packaging: Secure, lyophilized peptide powder in sealed vials.
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Research-Ready: Ideal for formulators looking to innovate anti-aging products.
Whether you’re developing advanced anti-aging serums or testing peptide-enriched cosmetics, our Acetyl Hexapeptide-3 offers a powerful foundation ingredient backed by skincare science.
Suggested Uses
Although usually applied topically, Acetyl Hexapeptide-3 can be used in:
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Anti-Aging Serums
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Eye Creams
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Facial Moisturizers
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Wrinkle-Reducing Lotions
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Cosmeceutical Research Prototypes
Because this peptide acts at the molecular level to moderate muscle contraction pathways, it’s often paired with other collagen-boosting ingredients or moisturizing actives like hyaluronic acid and niacinamide to create full-spectrum anti-aging products.
Formulation & Stability
Acetyl Hexapeptide-3 is water soluble and stable under proper storage conditions when protected from heat and light. For optimal results, incorporate it into aqueous-based vehicles, and avoid harsh solvents that can degrade peptide integrity.
Safety & Precautions
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Intended for topical formulation research or cosmetic use only.
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Not approved as a drug or injectable therapeutic.
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Patch testing is recommended during formulation to verify compatibility with skin types.
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Store sealed in a cool, dry environment to maintain activity.
Although widely regarded as safe and non-toxic, individual skin sensitivities can vary, especially at higher concentrations.
Conclusion
Acetyl Hexapeptide-3 is a cornerstone peptide active in modern cosmetic formulations. Backed by research and widely used in skincare worldwide.
It’s an excellent choice for anti-aging applications that aim to smooth expression lines, improve texture and support youthful-looking skin.
As part of your formulation portfolio, Peptide Metabolic’s Acetyl Hexapeptide-3 delivers quality, purity, and performance you can trust.











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